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KMID : 0355820220430010063
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Korean Journal of Oral Anatomy
2022 Volume.43 No. 1 p.63 ~ p.73
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Effect of Noni in alveolar bone loss in ligature-induced periodontitis mice model
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Hong Hye-Rin
Jung Bo-Hyun
Yoo Ki-Yeon
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Abstract
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Noni (Morinda citrifolia L.), commonly used as a health supplement, has antioxidant and anti-inflammatory effects. This study aimed to investigate the effect of noni on periodontitis, a chronic inflammatory disease. Periodontitis was induced in mice by ligating the maxillary second molar teeth with a 6-0 silk suture. After ligation, 10% noni fruit juice (NFJ, 10% NFJ) and 20% NFJ were orally administered to mice for 14 days. Micro-computed tomography and Masson trichrome staining of the maxillary alveolar process were performed to examine alveolar bone loss and gingival epithelial histopathology. Results showed inhibition of alveolar bone loss and gingival epithelial inflammation in the maxillary alveolar bone of the 20% NFJ group This study indicates that NFJ administration can effectively prevent periodontal disease.
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KEYWORD
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periodontitis, noni, alveolar bone, gingival epithelium, inflammation
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